The Seventy Second was organized in Fremont, Sandusky County, Ohio from October through December 1861. It left for Camp Chase on January 24, 1862 with 900 men. On Feburary 17, 1862 it was mustered in at Columbus, Ohio and was ordered to Paducah, Kentucky where it placed under the command of General William Tecumseh Sherman.
The regiment was assigned to a brigade under Colonel Ralph P. Buckland and boarded the steamer Baltic which disembarked them at Pittsburg Landing and later they encamped near Shiloh Church. On April 6 through the 7 it was constantly in the front lines of the battle named after this small edifice. This was its first major battle that the regiment was engaged in and the begining of a long history that would not end until it was mustered out on September 11, 1865 at Vicksburg, Mississippi.
Its losses were 60 in battle and 238 by disease.